A new look at an old body: molecular determinants of Weibel-Palade body composition and von Willebrand factor exocytosis
S Hordijk, T Carter, R Bierings - Journal of Thrombosis and …, 2024 - jthjournal.org
Endothelial cells, forming a monolayer along blood vessels, intricately regulate vascular
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these
functions is the controlled secretion of Weibel-Palade bodies (WPBs) which are specialized
endothelial storage organelles housing a pre-synthesized pool of the hemostatic protein von
Willebrand factor (VWF) and various other hemostatic, inflammatory, angiogenic, and
vasoactive mediators. This review delves into recent mechanistic insights into WPB biology …
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these
functions is the controlled secretion of Weibel-Palade bodies (WPBs) which are specialized
endothelial storage organelles housing a pre-synthesized pool of the hemostatic protein von
Willebrand factor (VWF) and various other hemostatic, inflammatory, angiogenic, and
vasoactive mediators. This review delves into recent mechanistic insights into WPB biology …
A new look at an old body: molecular determinants of Weibel-Palade body composition and VWF exocytosis
S Hordijk, T Carter, R Bierings - Journal of Thrombosis and Haemostasis, 2024 - Elsevier
Endothelial cells, forming a monolayer along blood vessels, intricately regulate vascular
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these
functions is the controlled secretion of Weibel-Palade bodies (WPBs) which are specialized
endothelial storage organelles housing a pre-synthesized pool of the hemostatic protein von
Willebrand factor (VWF) and various other hemostatic, inflammatory, angiogenic, and
vasoactive mediators. This review delves into recent mechanistic insights into WPB biology …
hemostasis, inflammatory responses, and angiogenesis. A key determinant of these
functions is the controlled secretion of Weibel-Palade bodies (WPBs) which are specialized
endothelial storage organelles housing a pre-synthesized pool of the hemostatic protein von
Willebrand factor (VWF) and various other hemostatic, inflammatory, angiogenic, and
vasoactive mediators. This review delves into recent mechanistic insights into WPB biology …
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